Fig. 6. Summary of the interaction and activity of neurotransmitters on QseC of E. coli. QseC is the quorum-sensing sensor kinase which is part of the quorum sensing regulation in various Gram-negative bacteria. Interestingly, EPI (adrenalin) triggers an adrenergic signaling cascade by interacting with the bacterial QseC involving dephosphorylation of QseB; whereas PTL acts as antagonist. Our in silico modeling showed that TA and DOP can bind to QseC but they have no the effect on kinase activity of QseB.